ICT For Life Sciences Forum

Flexible, active brain-computer interfaces for epilepsy – Professor Brian Litt

**REGISTRATIONS CLOSED*** 6 PM, Thursday, 13th September, 2012
Arrays of electrodes for recording and stimulating the brain are used throughout
clinical medicine and basic neuroscience research, yet are unable to sample large
areas of the brain while maintaining high spatial resolution because of the need
to individually wire each passive sensor at the electrode-tissue interface.

To overcome this constraint, we developed new devices that integrate ultrathin
and flexible silicon nanomembrane transistors into the electrode array, enabling
new dense arrays of thousands of amplified and multiplexed sensors that are
connected using fewer wires. We used this system to record spatial properties of
the brain activity in vivo, including sleep spindles, single-trial visual evoked
responses and electrographic seizures.

We found that seizures may manifest as recurrent spiral waves that propagate in
the neocortex. These developments herald a new generation of diagnostic and
therapeutic brain-machine interface devices.

Brian Litt is currently Professor of Neurology and Bioengineering at University of Pennsylvania. Previously he has held positions at the John Hopkins Hospital, John Hopkins University and Harvard University.
He is the recipient of numerous awards and honours, including the Hans Berger Award for Contribution to EEG Research, a member of the American Neurological Association, the Dreifuss-Penry Award for Epilepsy Research and the American Epilepsy Society Award for Innovative Research.
The Litt lab focuses on applying engineering technology to mapping and modulating functional networks in brain to understand and treat human disease, particularly epilepsy. The lab innovates in the areas of hardware design, machine learning, brain-computer interfaces, and translating this work into implantable devices. Our collaborative group is composed of clinical and experimental scientists and engineers. The lab emphasizes training in research, hosting 15 doctoral candidates and 10 post-doctoral researchers during the past five years.


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6 PM, Thursday, 13th September, 2012
(Please note refreshments served from 5 PM)
Brown Lecture Theatre,
Building 193 (Dept of Electrical & Electronic Engineering),
Wilson Ave, The University of Melbourne, Parkville, 3010.